Homood Moqbel R As Sobeai, MSc, PhD
Vice Dean for Graduate Studies and Scientific Research
Associate Professor, Pharmacology and Toxicology
College of Pharmacy, King Saud University
Riyadh 11451, Saudi Arabia
Office: 2A96 (Building 23)
Email:hassobeai @ksu.edu.sa

Professional summary

Dr. Homood As Sobeai holds the position of Associate Professor and serves as the Vice Dean for Graduate Studies and Scientific Research at the College of Pharmacy, King Saud University. He obtained his bachelor's degree from the College of Pharmacy, King Saud University, in 2009. Subsequently, he pursued and earned a Ph.D. in pharmaceutical sciences with an emphasis on molecular medicine and pharmacogenomics at Nova Southeastern University, Fort Lauderdale, Florida, USA, in 2017. Dr. As Sobeai's research objectives focus on identifying novel therapeutics to treat several types of cancer, studying the role of senescent cancer cells in driving tumor recurrence, and screening for genetic and epigenetic factors influencing cancer etiology and progression. Dr. As Sobeai has secured several national and institutional funding grants for his work. He has generated work that has been published in respected journals and presented at national and international scientific meetings.

Research Interests:

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Current and previous graduate and PharmD students

Key publication / select publication

Please see for a complete list of publication at:

• Alhazzani K, Mohammed H, Algahtani MM, Aljerian K, Alhoshani A, As Sobeai HM, Ahamad SR, Alotaibi MR, Alhamed AS, Alasmari F, Alqinyah M, Alhamami HS, Alanazi HZ. Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan’s Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats. Drug Design, Development and Therapy. 2024 Dec; 18, 5641-54. https://www.tandfonline.com/doi/full/10.2147/DDDT.S497212

• Alshamrani AA, Salman SBB, Alsaleh NS, Assiri MA, Almutairi MM, Almudimeegh S, Alwhaibi A, As Sobeai HM. miRNA-driven sensitization of breast cancer cells to Doxorubicin treatment following exposure to low dose of Zinc Oxide nanoparticles. Saudi Pharm. J. 2024 Nov; 32(11), 102169. https://doi.org/10.1016/j.jsps.2024.102169

• Albaqami WF, Alshamrani AA, Almubarak AA, Alotaibi FE, Alotaibi BJ, Alanazi AM, Alotaibi MR, Alhoshani A, As Sobeai HM. Genetic and Epigenetic Biomarkers Associated with Early Relapse in Pediatric Acute Lymphoblastic Leukemia: A Focused Bioinformatics Study on DNA-Repair Genes. Biomedicines. 2024 Aug; 12(8),1766. https://doi.org/10.3390/biomedicines12081766

• Binobaid L*, As Sobeai HM*, Alhazzani K, AlAbdi L, Alwazae MM, Alotaibi MR, Parrington J, Alhoshani AR. Whole-exome sequencing identifies cancer-associated variants of the endo-lysosomal ion transport channels in the Saudi population. Saudi Pharm. J. 2024 Mar; 32(30), 101961. https://doi.org/10.1016/j.jsps.2024.101961 *Shared first author.

• Alsaleh NB, Aljarbou AM, Assal ME, Assiri MA, Almutairi MM, As Sobeai HM, Alshamrani AA, Almudimeegh S, Hatshan MR, Adil SF. Synthesis, Characterization, and Toxicity Assessment of Zinc Oxide-Doped Manganese Oxide Nanoparticles in a Macrophage Model. Pharmaceuticals. Jan 2024; 17(2), 168. https://doi.org/10.3390/ph17020168

• Hanbashi A, Alotaibi MR, As Sobeai HM, Binobaid L, Alhazzani K, Kamli F, Jin X, Alhoshani AR, Parrington J. Loss of two-pore channel two function in melanoma-derived tumors reduces tumor growth in vivo but greatly increases tumor-related toxicity in the organism. Cancer Cell Int.. Dec 2023; 23(1), 325. https://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03148-6

• Softah A, Alotaibi MR, Alhoshani AR, Saleh T, Alhazzani K, Almutairi MM, Alrowais R, AlshehriS , Albekairi NA, Harada H, Boyd R, Chakraborty E, Gewirtz DA, As Sobeai HM. The combination of radiation with PARP inhibition enhances senescence and sensitivity to the senolytic, navitoclax, in triple negative breast tumor cells. Biomedicines. Biomedicines 2023 Nov; 11(11), 3066. https://doi.org/10.3390/biomedicines11113066

• Alsaleh NB, Assiri MA, Aljarbou AM, Almutairi MM, As Sobeai HM, Alshamrani AA, Almudimeegh S. Adverse Responses following Exposure to Subtoxic Concentrations of Zinc Oxide and Nickle Oxide Nanoparticles in the Raw 264.7 Cells. Toxics 2023 Aug; 11(8), 674. https://doi.org/10.3390/toxics11080674

• Alanazi AZ, Al-Rejaie SS, Ahmed MM, Alhazzani K, Alhosaini K, As Sobeai HM, Alsanea Sary, Alam P, Almarfadi OM, Alqahtani AS, Alhamed AS, Alqinyah M, Alhamami HN, Almutery MF, Mohany M. Protective role of Dodonaea viscosa extract against streptozotocin-induced hepatotoxicity and nephrotoxicity in rats. Saudi Pharm. J. 2023 Aug; 31 (8), 101669. https://doi.org/10.1016/j.jsps.2023.06.002

• Saleh T, As Sobeai HM, Alhoshani A, Alhazzani K, Almutairi MM, Alotaibi MR. Effect of autophagy inhibitors on radiosensitivity in DNA repair-proficient and-deficient glioma cells. Medicina. 2022 Jul; 58(6), 889. https://pubmed.ncbi.nlm.nih.gov/35888608/

• *Alhamhoom Y, *As Sobeai HM, Alsanea S, Alhoshani A. Aptamer‑based therapy for targeting key mediators of cancer metastasis(Review). Int J Oncol. 2022 Jun; 60(6), 1-15.

https://pubmed.ncbi.nlm.nih.gov/35425991/ *Shared first author

• Alanazi FE, As Sobeai HM, Alhazzani K, Al-Dhfyan A, Alshammari MA, Alotaibi MR, Al-hosaini K, Korashy HM, Alhoshani AR. Metformin attenuates V-domain Ig Suppressor of T-cell Activation Through the Aryl Hydrocarbon Receptor Pathway in Melanoma: in vivo and in vitro studies. Saudi Pharm. J. 2022 Feb; 30(2), 138-149.

https://doi.org/10.1016/j.jsps.2021.12.014

• As Sobeai HM, Alohaydib M, Alhoshani AR, Alhazzani K, Almutairi MM, Saleh T, Gewirtz DA, Alotiabi MR. Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells. Saudi Pharm. J. 2022 Jan; 30(1), 91-101. https://doi.org/10.1016/j.jsps.2021.12.004

• Alhoshani A, Alotaibi M, As Sobeai HM, Alharbi N, Alhazzani K, Al-Dhfyan A, Alanazi FE, Korashy HM. In vivo and in vitro studies evaluating the chemopreventive effect of metformin on the aryl hydrocarbon receptor-mediated breast carcinogenesis. Saudi J Biol Sci. 2021 Dec; 28(12), 7396-7403. https://www.sciencedirect.com/science/article/pii/S1319562X21007403

• Alhazzani K, Alotaibi MR, Alotaibi FN, Aljerian K, As Sobeai HM, Alhoshani AR, Alanazi AZ, Alanazi WA, Alswayyed M. Protective effect of valsartan against doxorubicin‐induced cardiotoxicity: Histopathology and metabolomics in vivo study. J Biochem Mol Toxicol. 2021 Jul; 35 (9), e22842 https://doi.org/10.1002/jbt.22842

• As Sobeai HM, Sulaiman AA, Ahmad S, Shaikh A, Sulaimon R, Alotiabi MR, AlZoghaibi F, Altoum AO, Isab AA, Alhoshani AR. Synthesis, characterization, and miRNA-mediated PI3K suppressing activity of novel cisplatin-derived complexes of selenones. Arab. J. Chem. 2021 Jul; 14(7), 103245.

https://doi.org/10.1016/j.arabjc.2021.103245

• Attia SM, Ahmad SF, Nadeem A, Attia MS, Ansari MA, As Sobeai HM, Al-Mazroua HA, Alasmari AF, Bakheet SA. 3-Aminobenzamide alleviates elevated DNA damage and DNA methylation in a BTBR T+ Itpr3tf/J mouse model of autism by enhancing repair gene expression. Pharmacol. Biochem. Behav. 2020 Dec; 199, 173057.

https://doi.org/10.1016/j.pbb.2020.173057

• Alasmari AF, Ali N, Alasmari FF, Alanazi WA, Alshammari MA, Alharbi NO, Alhoshani AR, As Sobeai HM, Alswayyed MM, Alghamdi NS. Liraglutide attenuates gefitinib-induced cardiotoxicity and promotes cardioprotection through the regulation of MAPK/NF-κB signaling pathways. Saudi Pharm. J. 2020 Apr; 28(4), 509-518.

https://pubmed.ncbi.nlm.nih.gov/32273812/

• Alotaibi MR, As Sobeai HM, Alaqil FA, Alhoshani AR, Almutairi MM, Alhazzani K, Sulaiman A, Isab A, Alotaibi N. A Newly Synthesized platinum-based Compound (PBC-II) Increases Chemo-sensitivity of HeLa Ovarian Cancer Cells Via Inhibition of Autophagy. Saudi Pharm. J. 2019 Dec; 27(8), 1203–1209.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921179/

• Al-Hamamaha MA, Alotaibia MR, Ahmada SF, Ansaria MA, Attia MS, Nadeem A., Bakheet SA, As Sobeai HM, Attia SM. Genetic and epigenetic alterations induced by the small-molecule panobinostat: A mechanistic study at the chromosome and gene levels. DNA Repair (Amst). 2019 Jun; 78, 70-80.

https://www.ncbi.nlm.nih.gov/pubmed/30978576

• Ibrahim OM*, As Sobeai HM*, Grant SG, Latimer JJ. Nucleotide excision repair (NER) gene expression in childhood acute lymphocytic leukemia is a predictor of early relapse. BMC Medical Genomics. 2018 Oct 30;11(1), 95. https://doi.org/10.1186/s12920-018-0422-2 *Shared first author.